Massive multiple-input multiple-output (MIMO) technology is expected to achieve significant gains in both signal-to-noise-plus-interference ratio (SINR) and throughput for 5G cellular wireless networks. Efficient and highly accurate channel state information (CSI) acquisition at the base stations (BS) is essential to achieve the potential benefits of massive MIMO systems. However, the inadequate number of orthogonal pilot sequences used for CSI estimation leads to erroneous channel estimation as it causes interference between pilot sequences. This phenomenon is coined pilot contamination and severely limits the system performance. Therefore, we address in this paper the pilot contamination problem in massive MIMO Cloud-Radio Access Networks systems. Leveraging on a real telecom operator data delivered by Call Detail Records (CDR), our objective is to maximize the average uplink achievable rate by reducing the effect of pilot contamination in massive MIMO Cloud-Radio Access Networks (C-RAN). As such a problem is a non-linear integer problem that has no solution in polynomial time, we develop a two-stage solution to solve it. First, a coalition game is proposed where Remote Radio Heads (RRHs) gather into clusters with random user-pilot allocation. Then, two greedy heuristics are applied to match each user in the cluster with a given pilot. The goal is to further improve the average uplink rate achieved in the first stage. Simulation results show that our heuristic solutions for pilot contamination mitigation outperform the traditional pilot allocation solution and a state-of-the-art pilot allocation scheme based on large-scale fading in terms of average uplink achievable rate and SINR.