ACETYLCHOLINESTERASE Cell model ARN AAV Knockout Trinucleotide Repeat Expansion Endurance training Expression Dystrophie myotonique Exercise Antisense oligonucleotide CRISPRi Dystrophie Myotonique Fibrosis Centronuclear myopathy Brain dysfunction Muscular dystrophy Mouse models Acute coronary syndrome PacBio Myotonic Dystrophy Type 1 CTG repeats Myotonic dystrophy type 1 Gene editing Muscle GSK3␤ Exercice RNA interference Trinucleotide repeat expansion Glucocorticoid-receptor Brain Transcriptomics DM1 Cardiac muscle Therapy Myotonic Dystrophy type 1 Intermediate filament Oligodendrocyte Motoneuron Cytoskeleton CRISPR/Cas9 Myotonic dystrophy mouse models Dystrophin DMSXL mice CTG repeat contractions Glucocorticoids Glutamate Male Alternative splicing Neuron Transgenic mouse model Dynamin 2 Heart failure Mice Animals Myelin Astrocyte Diaphragm Oligodendrocytes Autophagy CONGENITAL MYATHENIC SYNDROME Acetylcholinesterase knockout mouse Gene Therapy RNA biology Humans Genotype phenotype correlation PCR BIOLOGIE MOLECULAIRE Myotonic dystrophy Quantitative microdialysis Dilated cardiomyopathy Transgenic mouse Antisense oligonucleotides Cell culture model Heart GABA Cell penetrating peptide Aging Thérapie génique Astrocytes CTG repeat instability Myostatin DMPK KNOCKOUT MICE Myotonic Dystrophy Gene therapy Hypoxia Glial cells Skeletal muscle Desmin Duchenne muscular dystrophy Long read sequencing MBNL Central nervous system CMS Maximal force Mouse model In vivo Acetylcholinesterase deficiency RNA splicing